01322nas a2200277   4500000000100000008004100001260001300042653001000055653001100065653001200076653001600088653002500104653002500129653001800154653002900172653002300201653001800224653000900242100001300251700001300264245007900277300001000356490000700366520065700373022001401030       1986                            d  c1986 Jan10aAxons10aHumans10aleprosy10aMacrophages10aMicroscopy, Electron10aMycobacterium leprae10aMyelin Sheath10aNerve Fibers, Myelinated10aNerve Regeneration10aSchwann Cells10aSkin1 aIMAEDA T1 aImaeda H00aElectron microscopy of Mycobacterium leprae in cutaneous nerve components.  a59-610 v373 a<p>Cutaneous nerves in lepromatous lesions from ninety-six patients were observed by electron microscopy. The regenerative process of myelinated fibers was evident within lepromatous tissues. Intact or degenerative forms of Mycobacterium leprae were surrounded by the electron transparent substance within the axoplasm and Schwann cell cytoplasm. In contrast, the microenvironment of M. leprae in macrophages was characterized with fusing lysosomes and foamy structures. These results suggest that the electron transparent substance may be derived from bacterial metabolites and also that the foamy structure may originate from lysosomal substance.</p>  a0011-4162