01957nas a2200385   4500000000100000008004100001260001700042653001500059653001000074653001000084653001600094653001200110653003000122653001600152653001100168653001100179653002300190653001200213653000900225653002300234653001300257653001200270100001300282700001300295700001500308700001200323700001400335700001200349700001400361245013100375300001000506490000600516520103500522022001401557       1986                            d  c1986 Jan-Mar10aAdolescent10aAdult10aChild10aClofazimine10aDapsone10aDrug Therapy, Combination10aEthionamide10aFemale10aHumans10aLeprostatic Agents10aleprosy10aMale10aPatient Compliance10aRifampin10aSenegal1 aMillan J1 aBodian M1 aNaudin J C1 aDiouf B1 aBoucher P1 aNdoye B1 aGrosset J00a[A trial of polychemotherapy of leprosy in the Dakar region. Initial observations on the acceptability of the protocols used].  a19-350 v43 a<p>Since 1982, in Dakar, a controlled essay tests the suitability of several short protocols of multidrug therapy (MDT), some of them being close to those advised by the WHO, others showing a starter stage of a two month daily MDT. In three years, 198 paucibacillary and 123 multibacillary patients have been treated. The short duration of these treatments leads to an important decrease in the load of the Department. The total rate of those who have not attended for the treatment is of 15.2% whereas it was of 52% with DDS monotherapy for a similar treatment duration. Those who gave up don't seem to live in Dakar. To judge by the diligence of the patients, the compliance seems excellent even for the protocols requiring a daily dose of ethionamide: 95% of paucibacillary, 76% of multibacillary patients have maximal attendance. The authors think that any MDT program: must be preceded by a retraining of staffs; must give a priority to the health education of the patients; must involve a home patient search for system.</p>  a0001-5938