02036nas a2200349   4500000000100000008004100001260001300042653001200055653002400067653001100091653001600102653003000118653002300148653001200171653002600183653000900209653002500218653002500243653002400268100001500292700001500307700001400322700001300336700001700349700001600366700001300382245012300395300001200518490000700530520113500537022001401672       1986                            d  c1986 Feb10aAnimals10aAntigens, Bacterial10aFemale10aGlycolipids10aHypersensitivity, Delayed10aImmunity, Cellular10aleprosy10aLymphocyte Activation10aMice10aMice, Inbred Strains10aMycobacterium leprae10aSpecies Specificity1 aKoster F T1 aTeuscher C1 aMatzner P1 aUmland E1 aYanagihara D1 aBrennan P J1 aTung K S00aStrain variations in the murine cellular immune response to the phenolic glycolipid I antigen of Mycobacterium leprae.  a495-5000 v513 a<p>The cellular immune response to the Mycobacterium leprae-specific phenolic glycolipid I was examined in inbred mice immunized with M. leprae by in vivo delayed cutaneous hypersensitivity and in vitro lymphocyte proliferation. Whereas all mouse strains responded to M.leprae-induced delayed-type hypersensitivity and lymphocyte proliferation, only BALB.K was responsive in both assays to the glycolipid. Responsiveness was determined in part by non-H-2 genes, while the influence of H-2 genes was not apparent. Among congenic BALB/c mice differing only at Igh-C allotype loci, variations in responsiveness were found in both delayed-type hypersensitivity and lymphocytes proliferation assays, indicating a possible role for Igh-C loci-linked genes. Unresponsiveness in the lymphocyte proliferation assay to the glycolipid was inherited as a dominant trait in one set of responder X nonresponder F1 progeny. We conclude that after immunization with M. leprae organisms, the cell-mediated responses to the glycolipid, endowed with a single carbohydrate epitope, are under polygenic control, predominantly non-H-2-linked genes.</p>  a0019-9567