01491nas a2200325   4500000000100000008004100001260001300042653001200055653001100067653001600078653001200094653001600106653000900122653002500131653002500156653001600181653001300197653001600210653001500226653001200241653001700253653002700270100001500297700001500312245013100327300001000458490000700468520067600475022001401151       1986                            d  c1986 Mar10aAnimals10aFemale10aFibroblasts10aleprosy10aMacrophages10aMale10aMicroscopy, Electron10aMycobacterium leprae10aNerve Crush10aNeuritis10aNeutrophils10aPhagosomes10aRabbits10aTibial Nerve10aWallerian Degeneration1 aChandi S M1 aChacko C J00aAn ultrastructural study of the response of traumatized rabbit tibial nerve to epineurial infection with Mycobacterium leprae.  a79-830 v543 a<p>Crushed rabbit tibial nerves were inoculated with a suspension of living Mycobacterium leprae at and just distal to the site of nerve trauma. The resulting changes occurring over a period of time from 40 min to 72 hr post-inoculation were studied electron microscopically. Bacilli were seen in perineurial cells and in macrophages that had infiltrated the perineurium adjacent to epineurial deposits of M. leprae. It is suggested that trauma may weaken the perineurial barrier and facilitate the transperineurial passage of phagocytes, some of which may be laden with M. leprae, and may thus be a means whereby M. leprae enter the endoneurium of peripheral nerves.</p>  a0148-916X