00849nas a2200169   4500000000100000008004100001260001300042653001100055653001800066653001200084100001100096245007000107300001100177490000700188520047000195022001400665       1986                            d  c1986 Jun10aHumans10aInterleukin-110aleprosy1 aBand H00aInterleukin 1--a possible mediator of neural fibrosis in leprosy.  a143-500 v203 a<p>Neural fibrosis in leprosy, the disease caused by the obligate intracellular bacterium, Mycobacterium leprae, is closely related to the cell-mediated immune response to this microorganism. The fibrosis appears to be due to soluble mediators released by the immune effector cells. Interleukin 1, a macrophage product that stimulates fibroblast migration, proliferation and synthetic activity, possesses the requisite properties to qualify for such a mediator.</p>  a0306-9877