01626nas a2200337   4500000000100000008004100001260001300042653001200055653002000067653002700087653001400114653001200128653000900140653000900149653001800158100001500176700001600191700001400207700001200221700001500233700001600248700001500264700001300279700001500292245009500307856009000402300001000492490000700502520076500509022001401274       1986                            d  c1986 Aug10aAnimals10aCercopithecidae10aDisease Models, Animal10aGranuloma10aleprosy10aMale10aSkin10aT-Lymphocytes1 aModlin R L1 aOrmerod L D1 aWalsh G P1 aRea T H1 aMeyers W M1 aBinford C H1 aMartin L N1 aWolf R H1 aGormus B J00aIn situ characterization of T lymphocyte subpopulations in leprosy in the mangabey monkey.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1542319/pdf/clinexpimmunol00119-0048.pdf  a260-40 v653 a<p>Leprosy in the mangabey monkey is an experimental model which is similar both clinically and histologically to human lepromatous leprosy. The immunopathology of these diseases was compared using monoclonal antibodies against T lymphocyte subpopulations in frozen tissue sections with an immunoperoxidase technique. In both mangabey and human lepromatous granulomas OKT4 (or Leu 3a) and Leu 2a cells were scattered among macrophages with greater numbers of Leu 2a as compared with OKT4 (or Leu 3a) cells. The results suggest that from an immunopathological standpoint experimental leprosy in mangabeys will provide a suitable model for the investigation of the pathogenesis of human lepromatous leprosy and for the evaluation of new antileprosy vaccines.</p>  a0009-9104