01176nas a2200325   4500000000100000008004100001260001300042653001000055653001200065653002000077653001200097653002200109653001100131653001400142653001100156653001200167653000900179653001600188100001300204700001200217700001500229700001300244700001000257700001100267245011800278300001000396490000700406520042300413022001400836       1988                            d  c1988 Apr10aAdult10aAspirin10aChloramphenicol10aDapsone10aDrug Interactions10aFemale10aHalf-Life10aHumans10aleprosy10aMale10aMiddle Aged1 aGarg S K1 aKumar B1 aShukla V K1 aBakaya V1 aLal R1 aKaur S00aPharmacokinetics of aspirin and chloramphenicol in normal and leprotic patients before and after dapsone therapy.  a204-50 v263 a<p>Pharmacokinetics of aspirin and chloramphenicol was studied in 16 normal and 16 patients suffering from leprosy. A significant increase (p less than 0.05) in the elimination half-life of chloramphenicol was observed before and after dapsone treatment in leprotic patients as compared with the normal volunteers, while no significant difference was observed in any of the pharmacokinetic parameters with aspirin.</p>  a0174-4879