01452nas a2200313   4500000000100000008004100001260001300042653001500055653001000070653001600080653000900096653001000105653001200115653003100127653001100158653001100169653001200180653000900192653001600201653002500217653001600242653001400258100001000272245002600282300001100308490000700319520079800326022001401124       1987                            d  c1987 Oct10aAdolescent10aAdult10aAge Factors10aAged10aChild10aDapsone10aDrug Resistance, Microbial10aFemale10aHumans10aleprosy10aMale10aMiddle Aged10aMycobacterium leprae10aSex Factors10aSingapore1 aTan T00aLeprosy in Singapore.  a617-210 v163 a<p>The incidence of leprosy in Singapore is declining over the past 20 years. More than one third of new cases are now over 50 years while no child under 5 years has been affected since 1970. Male to female ratio is 2:1. Indians are more significantly affected compared to the other races and a higher proportion has tuberculoid leprosy. Tuberculoid leprosy accounts for 50.4% of cases seen during the past decade. Case detections from household contacts is still worthwhile as it accounts for 3% to 13.5% of the yearly incidence of the disease. The first four cases of dapsone resistance was confirmed in 1969. Since then the yearly incidence of clinically diagnosed dapsone resistant cases averaged 2.9 per thousand. Hence, various regimens of multiple drug therapy have been instituted.</p>  a0304-4602