02113nas a2200409   4500000000100000008004100001260001300042653001000055653001100065653001900076653002100095653001100116653001400127653001100141653001400152653001200166653000900178653002500187653001300212653002200225653003000247100001400277700001500291700001300306700001700319700002200336700001300358700001200371700001400383245011800397856005100515300001100566490000700577050003200584520107300616022001401689       2004                            d  c2004 Sep10aAdult10aBrazil10aDNA, Bacterial10aElectromyography10aFemale10aGranuloma10aHumans10aIncidence10aleprosy10aMale10aMycobacterium leprae10aNeuritis10aPeripheral nerves10apolymerase chain reaction1 aJardim MR1 aChimelli L1 aFaria SC1 aFernandes PV1 aDa Costa Néri JA1 aSales AM1 aSarno E1 aAntunes S00aClinical, electroneuromyographic and morphological studies of pure neural leprosy in a Brazilian referral centre.  uhttps://leprosyreview.org/article/75/3/24-2253  a242-530 v75  aInfolep Library - available3 a<p>Nineteen patients with pure neural leprosy were analysed with clinical examination, electroneuromyography and histopathology of nerve biopsies. Clinical examination showed sensory loss (78.9%), paresis (78.9%), nerve enlargement (68.4%) and nerve pain (42.1%). Electroneuromyographic study revealed an axonal pattern in 18 patients (94.7%) and a demyelinating pattern in one (0.5%). Mononeuropathy multiplex was the most frequent presentation (78.9%), followed by mononeuropathy simplex (10.5%) and polyneuropathy (10.5%). The histopathological study showed the presence of inflammatory infiltrate composed of epithelioid granuloma (42.1%), mononuclear infiltrate (36.8%) or macrophages positive for bacilli (21%). Fibrosis was present in 78.9% of the biopsies. Examination of semithin sections revealed, besides inflammatory infiltrate, myelinated fibre loss (94.7%), remyelination (42%), axonal degeneration (10%) as well as regeneration (31.5%). Based on these results, the pathogenesis of leprosy neuropathy in this group of patients is briefly discussed.</p>
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