01723nas a2200325   4500000000100000008004100001260001700042653001200059653002600071653002900097653002400126653002100150653002300171653001200194653002000206653002600226653001600252653000900268653002500277100001600302700001100318700001200329700001600341245011800357300001100475490000700486050003200493520085800525022001401383       1987                            d  c1987 Oct-Dec10aAnimals10aAntibodies, Bacterial10aAntigen-Antibody Complex10aAntigens, Bacterial10aImmune Tolerance10aImmunity, Cellular10aleprosy10aLeukocyte Count10aLymphocyte Activation10aLymphocytes10aMice10aMycobacterium leprae1 aVaishnavi C1 aKaur S1 aKumar B1 aGanguly N K00aRole of immune complexes in alteration of lymphocyte subpopulation numbers and functions in experimental leprosy.  a452-610 v59  aInfolep Library - available3 a<p>Swiss albino mice (normal as well as thymectomised and irradiated were inoculated into the footpads with Mycobacterium leprae and divided into two main phases of study. Phase I comprised of animals not given preformed immune complexes (IC). Uninfected controls were however included. Phase II consisted of animals given in vitro prepared IC at zero day period (OdIC), three month period (3mIC) or six month period (6mIC) to both uninfected and infected groups. Splenic lymphocytes were isolated to quantify T and B cells and their responses to M. leprae antigen and four different mitogens. Significant decrease in T cell counts and blast transformation was seen in the M. leprae infected animals which were also administered with immune complexes. Immunosuppression by IC was therefore seen to be enhanced in the presence of M. leprae infection.</p>  a0254-9395