01921nas a2200385   4500000000100000008004100001260001300042653001200055653003100067653001100098653001200109653001500121653002500136653001800161653001000179653001400189653001200203653001600215100002200231700001500253700002500268700001300293700001200306700001200318700001400330700001400344700001800358700001300376245015000389856004100539300001000580490000700590520092400597022001401521       1987                            d  c1987 Dec10aDapsone10aDrug Resistance, Microbial10aHumans10aleprosy10aMartinique10aMycobacterium leprae10aNew Caledonia10aParis10aPolynesia10aSenegal10aWest Indies1 aGuelpa-Lauras C C1 aCartel J L1 aConstant-Desportes M1 aMillan J1 aBobin P1 aGuidi C1 aBrucker G1 aFlageul B1 aGuillaume J C1 aPichet C00aPrimary and secondary dapsone resistance of M. leprae in Martinique, Guadeloupe, New Caledonia, Tahiti, Senegal, and Paris between 1980 and 1985.  uhttp://ila.ilsl.br/pdfs/v55n4a09.pdf  a672-90 v553 a<p>Primary and secondary dapsone resistance were studied among lepromatous patients living in Martinique, Guadeloupe, New Caledonia, Tahiti, Senegal, and Paris. Four hundred fifteen biopsies were taken from clinically active and bacteriologically positive (bacterial index greater than 2) patients in the 6-year period of 1980-1985. Among these, 280 biopsies that contained 5 x 10(4) acid-fast bacilli per ml with a morphological index of at least 0.10 were inoculated into the mouse foot pad, and 229 harbored infective Mycobacterium leprae. Among the 129 infective M. leprae isolated from new cases, 54% had some degree of dapsone resistance, a low degree being prominent in all cases. Among the 100 infective M. leprae isolated from relapsed cases, 79% had a high or an intermediate degree of dapsone resistance. The annual incidence of secondary dapsone resistance was estimated to be about 0.55% in Guadeloupe.</p>  a0148-916X