01280nas a2200253   4500000000100000008004100001260001300042653001200055653001200067653000900079653001500088653002500103653001300128100002800141700001000169700001400179700002200193700001600215245012200231300001100353490000700364520064100371022001401012       1987                            d  c1987 Dec10aAnimals10aleprosy10aMice10aMice, Nude10aMycobacterium leprae10aRifampin1 aMcDermott-Lancaster R D1 aIto T1 aKohsaka K1 aGuelpa-Lauras C C1 aGrosset J H00aMultiplication of Mycobacterium leprae in the nude mouse, and some applications of nude mice to experimental leprosy.  a889-950 v553 a<p>Two aspects of the immune deficiency of nude mice make these animals particularly useful tools for leprosy research. Nude mice are capable of supporting multiplication of M. leprae to levels approaching 10(10) per g in peripheral body tissues. In addition, nude mice may be inoculated with greater than 10(4) (in fact, with as many as 10(8) organisms per foot pad, without provoking an immune response that prevents multiplication of the organisms. Thus, the nude mouse should be particularly suitable for detecting persisting M. leprae in treated patients, and as a model of the patient for evaluating chemotherapeutic regimens.</p>  a0148-916X