01432nas a2200241   4500000000100000008004100001260001700042653001600059653003000075653001100105653002500116653001400141653001200155653001300167100001300180700001300193700001700206245010500223300001100328490000600339520083100345022001401176       1987                            d  c1987 Apr-Jun10aClofazimine10aDrug Therapy, Combination10aHumans10aIndian Ocean Islands10aIsoniazid10aleprosy10aRifampin1 aCnudde F1 aJulvez J1 aRivière J P00a[Short-term clinical and histological evaluation of combination drug therapy of leprosy in Mayotte].  a115-240 v53 a<p>Leprosy in Mayotte affects 480 persons in a population of 80,000 inhabitants. 229 patients have been treated every day by association of Rifampicin, Clofazimine and Isoniazide. This study make a clinical, histological and bacteriological valuation after treatment, during a period of 3 years. With paucibacillary patients, whom received 1 year of mean treatment and after 2 years under observation, histology for short-dated can stay positive and active. With multibacillary patients, whom received 26 months of mean treatment and most of the time after 1 year under observation, the all of morphological index is negative, sometime bacteriology is positive, less often than histology. For middle- and long-dated, histology should allow a good valuation for disease evolution, specially for interpolar leprosy patients.</p>  a0001-5938