01224nas a2200241   4500000000100000008004100001260001700042653001200059653001100071653001200082653001500094653001300109100001500122700001500137700001500152700001500167700001500182245008800197300001000285490000600295520066700301022001400968       1986                            d  c1986 Oct-Dec10aDapsone10aHumans10aleprosy10aRecurrence10aRifampin1 aPattyn S R1 aHusser J A1 aJanssens L1 aGrillone S1 aBourland J00a[Inadequate treatment in multibacillary leprosy and incubation times for relapses].  a495-90 v43 a<p>Among a population of over 500 PB patients treated with different regimens, 6 multibacillary relapses were detected: 5 in patients erroneously classified as PB but in reality MB with a low bacterial load, one patient was PB at the start. Treatment regimens had been: 10 weekly doses of RMP either 600 mg (1 case) or 900 mg (1 case) two successive doses of RMP 1500 mg (1 case) a single dose of RMP 40 mg/K (3 cases). Four MB patients with proven DDS-R relapsed after a single dose of RMP either 20 mg/K (1 case) or 40 mg/K (3 cases). The two strains isolated were RMP sensitive. Seven of the 10 relapses appeared within 24 months after start of treatment.</p>  a0001-5938