01170nas a2200277   4500000000100000008004100001260001300042653002400055653001100079653003000090653001300120653001400133653002500147653001500172100001500187700001200202700001100214700001600225700001400241245012900255300000900384490000700393050001800400520046000418022001400878       1988                            d  c1988 Mar10aAntigens, Bacterial10aHumans10aHypersensitivity, Delayed10aLepromin10aLiposomes10aMycobacterium leprae10aSkin Tests1 aSengupta U1 aSinha S1 aRamu G1 aLavania R K1 aGupta C M00aSoluble antigen of M. leprae coupled with liposomes elicits both "early" and "late" delayed hypersensitivity skin reactions.  a45-90 v56  aSENGUPTA 19883 a<p>The soluble antigen(s) of Mycobacterium leprae was(were) coupled to liposomes and used for skin testing of leprosy patients, hoping that this mode of antigen presentation would be identical to that of integral lepromin. The liposomized antigen(s) elicited both early (24-48 hr) and late (3-4 weeks) delayed-type hypersensitivity reactions, true to the nature of lepromin, unlike the soluble antigen(s) alone which elicit(s) only the early reaction.</p>  a0148-916X