01947nas a2200373   4500000000100000008004100001260001300042653001200055653003200067653003100099653001100130653002000141653001100161653001200172653001400184653000900198653002700207653001200234100001200246700001400258700001500272700001200287700001300299700001000312700001300322700001300335700001100348700001300359245008700372300001000459490000700469520108300476022001401559       2003                            d  c2003 Mar10aAlleles10aChromosomes, Human, Pair 1010aChromosomes, Human, Pair 610aFemale10aGenetic Linkage10aHumans10aleprosy10aLod Score10aMale10aMicrosatellite Repeats10aVietnam1 aMira MT1 aAlcaïs A1 aVan Thuc N1 aThai VH1 aHuong NT1 aBa NN1 aVerner A1 aHudson T1 aAbel L1 aSchurr E00aChromosome 6q25 is linked to susceptibility to leprosy in a Vietnamese population.  a412-50 v333 a<p>Leprosy, a chronic infectious disease caused by Mycobacterium leprae, affects an estimated 700,000 persons each year. Clinically, leprosy can be categorized as paucibacillary or multibacillary disease. These clinical forms develop in persons that are intrinsically susceptible to leprosy per se, that is, leprosy independent of its specific clinical manifestation. We report here on a genome-wide search for loci controlling susceptibility to leprosy per se in a panel of 86 families including 205 siblings affected with leprosy from Southern Vietnam. Using model-free linkage analysis, we found significant evidence for a susceptibility gene on chromosome region 6q25 (maximum likelihood binomial (MLB) lod score 4.31; P = 5 x 10(-6)). We confirmed this by family-based association analysis in an independent panel of 208 Vietnamese leprosy simplex families. Of seven microsatellite markers underlying the linkage peak, alleles of two markers (D6S1035 and D6S305) showed strong evidence for association with leprosy (P = 6.7 x 10(-4) and P = 5.9 x 10(-5), respectively).</p>  a1061-4036