02155nas a2200349   4500000000100000008004100001260001300042653001800055653001700073653001100090653003000101653001200131653003100143653000900174653001800183653002000201653002800221100001300249700001500262700001300277700001400290700001500304700001400319700001400333700001500347245014300362856008800505300001100593490000700604520118000611022001401791       1988                            d  c1988 Dec10aCell Movement10aHemophilia A10aHumans10aHypersensitivity, Delayed10aleprosy10aLung Diseases, Obstructive10aSkin10aT-Lymphocytes10aTuberculin Test10aTuberculosis, Pulmonary1 aBeck J S1 aMorley S M1 aLowe J G1 aBrown R A1 aGrange J M1 aGibbs J H1 aPotts R C1 aKardjito T00aDiversity in migration of CD4 and CD8 lymphocytes in different microanatomical compartments of the skin in the tuberculin reaction in man.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2013285/pdf/brjexppathol00006-0017.pdf  a771-800 v693 a<p>The lymphocytes in the perivascular foci of tuberculin skin tests have a similar CD4:CD8 ratio to those in the peripheral blood, suggesting that these subsets do not show bias in their initial emigration. By contrast, the diffusely infiltrating lymphocytes show a relative preponderance of CD4 cells which is progressively greater in successive 250 micron layers into the dermis. A generally similar pattern is seen in healthy controls and in patients with untreated pulmonary tuberculosis, treated leprosy, haemophilia A and chronic obstructive lung disease (COLD) patients treated with prednisolone, but the gradient of increasing CD4:CD8 ratio with depth into the dermis is significantly less steep in patients with tuberculosis, haemophilia and prednisolone-treated COLD than in the healthy controls. Selective migration results in a relative preponderance of CD4 cells in the diffuse infiltrate and it is suggested that this is a mechanism likely to potentiate defensive reaction to Mycobacterium tuberculosis: any deficiency in selective migration may make immunological defences less effective and so contribute to the chronicity of the lesions of tuberculosis.</p>  a0007-1021