02131nas a2200397   4500000000100000008004100001260001300042653001500055653001000070653001200080653001400092653003300106653003500139653001700174653001100191653001200202653002400214653000900238653002400247653001100271653001700282653001700299100001500316700001800331700001200349700001200361700001000373700001100383700001100394245010000405300001200505490000600517050001500523520118100538022001401719       1977                            d  c1977 Apr10aAdolescent10aAdult10aAtrophy10aEstradiol10aFollicle Stimulating Hormone10aGonadotropin-Releasing Hormone10aGynecomastia10aHumans10aleprosy10aLuteinizing Hormone10aMale10aTesticular Diseases10aTestis10aTestosterone10aTime Factors1 aMorley J E1 aDistiller L A1 aSagel J1 aKok S H1 aKay G1 aCarr P1 aKatz M00aHormonal changes associated with testicular atrophy and gynaecomastia in patients with leprosy.  a299-3030 v6  aMORLEY19773 a<p>Basal LH, FSH, 17 beta-oestradiol and testosterone and the gonadotrophin responses to luteinizing hormone releasing hormone (LHRH) were studied in male patients with leprosy (twenty-four with lepromatous and six with tuberculoid leprosy). The mean basal LH and FSH was significantly elevated in the lepromatous group and was associated with an excessive response of both gonadotrophins following LHRH administration. The mean basal testosterone and 17 beta-oestradiol values in the lepromatous group were significantly lower than those of the tuberculoid and control groups. The abnormal gonadotrophin and sex steroid values in the lepromatous group are in keeping with the testicular atrophy and gynaecomastia accompanying this form of leprosy. However, the lack of a significant correlation between basal FSH and testicular atrophy should be noted. In addition, no correlation between any of these hormonal values and gynaecomastia could be demonstrated. The patients with tuberculoid leprosy had essentially normal hormonal profiles (except for two who had raised 17 beta-oestradiol values). This is compatible with the lack of gonadal involvement in these patients.</p>  a0300-0664