01586nas a2200409   4500000000100000008004100001260001300042653002800055653001200083653001800095653001800113653001700131653001100148653002300159653003300182653002200215653000900237653001400246653001200260653001200272653001600284653002500300653001400325653001500339653002800354653002500382653001200407653001300419653001900432100001600451700001400467245003700481300001000518490000700528520062700535022001401162       1977                            d  c1977 Jun10aAdministration, Topical10aAnimals10aAqueous Humor10aChlorobutanol10aCiliary Body10aCornea10aDimethyl Sulfoxide10aDrug Administration Schedule10aDrug Combinations10aIris10aKeratitis10aLanolin10aleprosy10aMineral Oil10aMycobacterium leprae10aOintments10aPetrolatum10aPharmaceutical Vehicles10aPolyethylene Glycols10aRabbits10aRifampin10aUveal Diseases1 aFeldman M F1 aMoses R A00aCorneal penetration of rifampin.  a862-50 v833 a<p>We tested the corneal penetration of rifampin in four vehicles: dimethylsulfoxide, polyethylene glycol, an ocular lubricant, and as rifampin ointment. We measured drug concentrations in the aqueous humor in rabbits after topical instillation of 1 and 2.5% rifampin according to two dosage schedules. Drug concentrations in the aqueous humor were bactericidal to Mycobacterium leprae. Since leprosy of the cornea, iris, and ciliary body may develop despite standard systemic bacteriostatic treatment, treatment of leprotic involvement of the anterior eye may be enhanced by intensive topical application of rifampin.</p>  a0002-9394