01783nas a2200289   4500000000100000008004100001260001300042653001000055653001600065653001200081653003300093653003000126653001100156653001200167653000900179653001300188100002100201700001400222700001700236700001800253245009300271300001000364490000700374050003200381520106600413022001401479       1988                            d  c1988 Oct10aAdult10aClofazimine10aDapsone10aDrug Administration Schedule10aDrug Therapy, Combination10aHumans10aleprosy10aMale10aRifampin1 aRamakrishnan K R1 aArora P N1 aAggarwal S K1 aRamachandra S00aPaucibacillary leprosy: a comparative study of different schedules of multidrug therapy.  a542-80 v60  aInfolep Library - available3 a<p>The study was undertaken to evaluate the efficacy of various multidrug regimens (MDT). Three groups of 10 cases each of Paucibacillary cases were given different schedule of multidrug therapy. First group (T-0) was administered modified WHO regimen consisting of Rifampicin 600 mg once a month, Clofazimine 100 mg alternate days and Dapsone 100 mg daily for 6 months. In second group (T-1) Rifampicin 600 mg was given daily for 6 weeks and in third group (T-2) Rifampicin 600 mg was given daily for 6 months. In both the latter groups Clofazimine 100 mg on alternate days and Dapsone 100 mg daily was also administered for 6 months. Objective clinical scoring was done at the time of admission, three months and six months after treatment in all three groups. The best results were obtained by T-2 followed by T-1; and least effective was T-0 regimen. Pinkish colour of urine and skin was observed in 26 cases and icthyosis in all the cases. All the patients remain under treatment. The work is in progress and subsequent results will be published later.</p>  a0254-9395