01349nas a2200265   4500000000100000008004100001260000900042653002400051653001100075653002100086653001200107653002500119653001500144100001100159700001500170700001500185700001900200700001400219700001400233245009200247300001000339490000700349520071300356022001401069       1988                            d  c198810aAntigens, Bacterial10aHumans10aInterferon-gamma10aleprosy10aMycobacterium leprae10aSkin Tests1 aSuso L1 aNogueira N1 aVieira L M1 aFigueiredo A A1 aPorto J A1 aSarno E N00a[Correlation of skin tests and the production of gamma-interferon in leprosy patients].  a193-60 v163 a<p>The responsiveness of 25 leprosy patients to an in vitro correlate of cell-mediated immunity to M. leprae antigen, (the production of Y-IFN by peripheral blood mononuclear cells) was compared to their response to skin tests routinely used to evaluate cell-mediated immunity to a number of antigens including M. leprae. The results indicate that among the polar lepromatous patients (LL) there was a clear correlation between low responses in the in vitro assay (Y-IFN production), negative skin test to the specific antigen (Mitsuda reaction) and low responses to skin tests to a related antigen (PPD). There was no correlation in the other clinical groups with skin tests to other unrelated antigens.</p>  a0210-5187