01754nas a2200325   4500000000100000008004100001260001300042653001500055653001000070653001200080653003300092653003000125653001100155653001100166653001200177653000900189653001600198653002400214653001300238100001200251700001200263700001700275700001400292245008100306300001100387490000700398050003200405520097700437022001401414       1988                            d  c1988 Apr10aAdolescent10aAdult10aDapsone10aDrug Administration Schedule10aDrug Therapy, Combination10aFemale10aHumans10aleprosy10aMale10aMiddle Aged10aRemission Induction10aRifampin1 aKar P K1 aJha P K1 aPanayach J S1 aSnehi P S00aA clinico-pathological study of multidrug regimen in paucibacillary leprosy.  a235-410 v60  aInfolep Library - available3 a<p>Preliminary results of a clinical trial in one hundred untreated paucibacillary leprosy cases with multidrug therapy (MDT) as per WHO recommendation are presented. Out of 100 fresh cases studied 18 had indeterminate, 35 tuberculoid and 47 cases had borderline tuberculoid leprosy. All were given MDT consisting of rifampicin 600 mg once a month and dapsone 100 mg daily for six months. At the end of six months all the cases were evaluated clinically and histopathological examination of lesions were studied. The lesions were still active in 35% of patient clinically and 47% histologically. Complete histological resolution have come across only in 4 cases suffering from indeterminate leprosy. Altogether 65% cases receiving MDT have shown marked improvement to total inactivation. Histologically, lymphocytic infiltration still persisted in 90% of slides examined and nerve infiltration were still present in 64% of cases at the end of six months receiving MDT.</p>  a0254-9395