01460nas a2200289   4500000000100000008004100001260001300042653001200055653002900067653002400096653001200120653001600132653000900148653003900157653001500196653001700211100001600228700001600244700001200260700001100272245011000283300001100393490000700404050003200411520071300443022001401156       1988                            d  c1988 Apr10aAnimals10aAntigen-Antibody Complex10aChemotactic Factors10aleprosy10aMacrophages10aMice10aPhagocyte Bactericidal Dysfunction10aThymectomy10aTime Factors1 aVaishnavi C1 aGanguly N K1 aKumar B1 aKaur S00aEffect of in vitro formed immune complexes on macrophage functions of Mycobacterium leprae infected mice.  a242-510 v60  aInfolep Library - available3 a<p>Nonspecific macrophage functions were studied in Mycobacterium leprae infected and preformed immune complex (IC) administered normal (NI) and thymectomized/irradiated (TRI) mice at different time periods. Uninfected controls given IC were also included. Significant decrease in the chemotaxis, phagocytosis and bactericidal activities of macrophages obtained from infected groups compared to their controls were observed. Phagocytic and chemotactic activities of macrophages were normal but intracellular killing was seen to be depressed in studies conducted in normal and thymectomized immunosuppressed groups (Vaishnavi et al., 1985, Kumar et al, 1987) which were not administered with preformed IC.</p>  a0254-9395