01549nas a2200349   4500000000100000008004100001260001300042653002400055653002400079653002300103653002000126653002100146653001000167653002100177653002400198653001100222653001200233653002800245653002500273653003100298653001700329100001200346700001500358700001400373700001500387700001400402245006800416300001200484490000700496520068200503022001401185       1988                            d  c1988 Jun10aAmino Acid Sequence10aAntigens, Bacterial10aCloning, Molecular10aCross Reactions10aEscherichia coli10aGenes10aGenes, Bacterial10aHeat-Shock Proteins10aHumans10aleprosy10aMolecular Sequence Data10aMycobacterium leprae10aMycobacterium tuberculosis10aTuberculosis1 aYoung D1 aLathigra R1 aHendrix R1 aSweetser D1 aYoung R A00aStress proteins are immune targets in leprosy and tuberculosis.  a4267-700 v853 a<p>To understand the immune response to infection by tuberculosis and leprosy bacilli and to develop improved vaccines, the nature of antigens that are involved in humoral and cell-mediated immunity was investigated. We have determined that five immunodominant protein antigens under study are homologues of stress proteins. This finding and observations with other pathogens suggest that infectious agents may respond to the host environment by producing stress proteins and that these proteins can be important immune targets. We postulate that abundant and highly conserved stress proteins may have "immunoprophylactic" potential for a broad spectrum of human pathogens.</p>  a0027-8424