01187nas a2200265   4500000000100000008004100001260001300042653002500055653001100080653002100091653001100112653002500123653002200148653002500170653002000195100001200215700001400227700001400241245009900255300001100354490000700365050003200372520050300404022001400907       1988                            d  c1988 Jul10aDNA-Binding Proteins10aHumans10aImmunoglobulin G10aLasers10aLeprosy, lepromatous10aMass Spectrometry10aProtein Conformation10aStereoisomerism1 aKumar R1 aBajaj M M1 aSwaroop B00aConformational changes in the IgG molecule of lepromatous sera using laser Raman spectroscopy.  a363-730 v60  aInfolep Library - available3 a<p>In the present work we report our studies on IgG separated from the serum of lepromatous patients and non-lepromatous leprosy cases using Laser Raman Spectroscopy. Striking spectral changes in LL cases have been observed in the following special regions: (a) the amide I and III, (b) the S-S and C-S stretching (c) the skeletal bending and (d) skeletal stretching regions. These changes indicate a decrease in the amount of beta-structure and a transition towards alpha-helical conformation.</p>  a0254-9395