01616nas a2200301   4500000000100000008004100001260001600042653003400058653001100092653001900103653001000122653001700132653001100149653001200160653000900172653001600181653001300197100001400210700002100224700001200245700001400257700001200271245004400283300001100327490000700338520095500345022001401300       1978                            d  c1978 Jun 0910aContinental Population Groups10aFemale10aGene Frequency10aGenes10aHLA Antigens10aHumans10aleprosy10aMale10aSex Factors10aThailand1 aGreiner J1 aSchleiermacher E1 aSmith T1 aLenhard V1 aVogel F00aThe HLA system and leprosy in Thailand.  a201-130 v423 a<p>To investigate immunogenetics of leprosy, 205 leprosy patients (26 with tuberculoid, 57 with borderline-tuberculoid, 21 with borderline, 31 with borderline-lepromatous, and 70 with lepromatous leprosy) have been typed for HLA antigens, and compared with 183 healthy controls from the same region (Northern Thailand). There was no significant difference between the overall group of leprosy patients or the three borderline classes and the controls. The two polar forms, tuberculoid and lepromatous leprosy, however, showed significant associations: HLA-A2 is decreased and HLA-Bw17 is increased in tuberculoid leprosy; HLA-B7 is increased in lepromatous leprosy. When both polar forms are compared with each other, HLA-A2 is significantly higher, HLA-Bw40 lower in patients with lepromatous than in those with tuberculoid leprosy. The results are discussed with respect to the different immune responsiveness in the two polar forms of leprosy.</p>  a0340-6717