01419nas a2200265   4500000000100000008004100001260001300042653001600055653001600071653001800087653002400105653003100129653002100160653001100181653001200192653001700204100001500221700001300236700001500249245011800264300001000382490000800392520073900400022001401139       1988                            d  c1988 Aug10aChloroquine10aClofazimine10aComplement C310aComplement Factor B10aComplement System Proteins10aErythema Nodosum10aHumans10aleprosy10aPrednisolone1 aSehgal V N1 aSharma V1 aSharma V K00aThe effect of anti-reactional drugs on complement components in the type II, erythema nodosum leprosum, reaction.  a255-80 v1193 a<p>Seventeen patients with the type II (erythema nodosum leprosum) (ENL) reaction were studied. They received multidrug therapy and also the anti-reactional drugs prednisolone clofazimine or chloroquin, and we measured serum levels of complement components before treatment and after the reaction had subsided. Factor B was significantly elevated after treatment with each of the three drugs. C3 levels were significantly increased after treatment, the largest change being in patients treated with clofazimine. In these patients there was also a concomitant decrease in C3d levels. This suggests that clofazimine has complement modulating activity and we would recommend it as the drug of choice in treatment of the ENL reaction.</p>  a0007-0963