01619nas a2200313   4500000000100000008004100001260001300042653001500055653001000070653002300080653001300103653001100116653001700127653001100144653001200155653000900167653001600176653001300192100001600205700001800221700002200239700002100261700001600282245004600298300001000344490000700354520093000361022001401291       1979                            d  c1979 Mar10aAdolescent10aAdult10aChromosome Mapping10aEpitopes10aFemale10aHLA Antigens10aHumans10aleprosy10aMale10aMiddle Aged10aThailand1 aChiewsilp P1 aAthkambhira S1 aChirachariyavej T1 aBhamarapravati N1 aEntwistle C00aThe HLA antigens and leprosy in Thailand.  a186-80 v133 a<p>HLA-A and -B locus antigens were determined in 170 unrelated patients with leprosy and 100 healthy controls. There were no statistically significant deviations from expected antigen distribution in patients with any of the various forms of leprosy, though the number of patients studied is relatively small. There were some interesting trends, particularly a possible decrease in the number of tuberculoid patients with A9, and an increase in the proportions of lepromatous patients with B18 and B40. Limited evidence of a genetically controlled pre-disposition to the clinical manifestations of leprosy suggests that further studies with extended typing should be carried out on the HLA haplotype segregation in informative leprosy families. These should provide a clearer indication of the relevance of the HLA (including DR) and possibly of other non-HLA loci to the possible mechanism(s) of disease susceptibility.</p>  a0001-2815