01367nas a2200301   4500000000100000008004100001260001300042653002200055653001200077653002600089653001000115653001300125653001400138653001100152653000900163653001600172653001100188653001700199653001300216653001300229100001400242700001500256245011600271300001000387490000800397520064600405022001401051       1988                            d  c1988 Oct10aAnemia, Hemolytic10aDapsone10aDrug Hypersensitivity10aFever10aHeadache10aHepatitis10aHumans10aMale10aMiddle Aged10aNausea10aSpider Bites10aSyndrome10aVomiting1 aWille R C1 aMorrow J D00aCase report: dapsone hypersensitivity syndrome associated with treatment of the bite of a brown recluse spider.  a270-10 v2963 a<p>Dapsone (4-4-diaminodiphenyl-sulfone) is a member of the sulfone group of antibiotics used in the treatment of leprosy and various dermatitidies and more recently employed in the management of local reactions to the bite of the brown recluse spider, Loxosceles reclusa. A dapsone hypersensitivity syndrome, consisting of fever, headache, nausea, vomiting, lymphadenopathy, hepatitis, hemolysis, leukopenia, and mononucleosis, has been described in patients treated with the drug for leprosy. A case report of the hypersensitivity syndrome occurring in a patient being treated with dapsone for a brown recluse spider bite is presented.</p>  a0002-9629