01852nas a2200325   4500000000100000008004100001260001300042653002200055653003800077653001900115653001700134653002500151653001000176653001100186653001000197653001200207653002600219653002800245100001400273700001400287700001400301700001500315700001600330700001700346245007700363300001100440490000700451520105400458022001401512       1988                            d  c1988 Dec10aBlotting, Western10aEnzyme-Linked Immunosorbent Assay10aHIV Antibodies10aHIV Antigens10aHIV Core Protein p2410aHIV-110aHumans10aIndia10aleprosy10aRetroviridae Proteins10aTuberculosis, Pulmonary1 aShivraj L1 aPatil S A1 aGirdhar A1 aSengupta U1 aDesikan K V1 aSrinivasan H00aAntibodies to HIV-1 in sera from patients with mycobacterial infections.  a546-510 v563 a<p>Sera from 478 persons (348 leprosy patients, 33 tuberculosis patients, 29 healthy contacts of leprosy patients, 38 normal healthy Indians, and 30 normal healthy Europeans) were screened for anti-HIV-1 IgG antibodies by ELISA. None was positive. In addition, 132 samples (from 43 leprosy patients, 21 tuberculosis patients, 5 healthy contacts of leprosy patients, 33 normal healthy Indians, and 30 normal healthy Europeans) were also tested by Western blot assay for anti-HIV-1 IgG antibodies. Only 1 of the 63 healthy subjects expressed a prominent p17 band. One or more bands were found in 44 (leprosy patients 33/43, tuberculosis patients 7/21, and leprosy contacts 4/5) of the remaining 69 sera. Antibody to the HIV-1-specific antigen p24 was expressed by 17 of these subjects (14/43 leprosy patients, 1/21 tuberculosis patients, and 2/5 leprosy contacts), either as a single band or in combination with other bands. This raises the possibility of a common antigenic pattern between HIV-1 and mycobacteria, especially Mycobacterium leprae.</p>  a0148-916X