02135nas a2200361   4500000000100000008004100001260001700042653001500059653001000074653001800084653001000102653001100112653003200123653001100155653002300166653000900189653001200198653002000210653000900230653001600239653002200255653001800277100001400295700001300309700001500322700001500337700001000352245009900362300001100461490000700472520128000479022001401759       1978                            d  c1978 Apr-Jun10aAdolescent10aAdult10aCell Movement10aChild10aFemale10aHistocompatibility Antigens10aHumans10aImmunity, Cellular10aIran10aleprosy10aLeukocyte Count10aMale10aMiddle Aged10aRosette Formation10aT-Lymphocytes1 aMassoud A1 aNikbin B1 aNazari G R1 aSyadat N A1 aAla F00aA study of cell-mediated immunity and histocompatibility antigens in leprosy patients in Iran.  a149-530 v463 a<p>Fifty-six male and 14 female leprosy patients, aged 11-62, were studied for cell-mediated immunity (CMI) and histocompatibility antigens. Healthy blood donors were used as normal controls. All patients were receiving antileprosy drugs. T and B cells were detected by E and EAC rosette formation technics, and the leukocyte migration test (LMT) was done in the presence of PHA. HLA antigens were defined by a modified N.I.H. lymphocytotoxicity test in order to type 48 patients and 100 controls. There was a significant difference (p less than 0.01) in the number of T cells between tuberculoid and lepromatous forms of the disease as compared to normal controls. We did not observe any differences in EAC rosette cells. It should be noted that the migration index is significantly higher in controls than in leprosy patients for PHA. There are no significant differences in the distribution of the A locus antigens between leprosy patients and controls, although a higher percentage of A-11 was obtained in leprosy patients. A slight elevation of B5 antigen was observed but these results are preliminary and our information regarding the B locus is incomplete. Thus, it is difficult to establish any precise relationship between HLA antigen and leprosy at this stage.</p>  a0148-916X