01498nas a2200289   4500000000100000008004100001260001300042653001500055653001000070653001100080653001100091653003000102653002300132653001200155653000900167653001600176653001800192100001300210700001700223700001500240700001500255245007400270300001100344490000700355520083200362022001401194       1978                            d  c1978 Oct10aAdolescent10aAdult10aFemale10aHumans10aImmune Adherence Reaction10aImmunity, Cellular10aleprosy10aMale10aMiddle Aged10aT-Lymphocytes1 aGeller M1 aFlaherty D K1 aAzulay R D1 aSurfus J E00aAbsence of inhibitory effect of leprosy sera upon normal E rosetting.  a649-510 v173 a<p>Inhibitory serum factors in certain infectious diseases (leprosy, tuberculosis, histoplasmosis) and malignant conditions (Hodgkin's disease, primary intracranial neoplasms) are said to be partially responsible for decreased cell-mediated immunity (CMI) and consequent anergy. The immunologic derangement in leprosy is not yet completely understood. In order to determine the effect of sera from patients with leprosy upon the rosetting capacity of normal T. lymphocytes, sera from untreated lepromatous (L) and tuberculoid (T) patients were studied. Control sera were obtained from normal volunteers and from patients with other dermatologic conditions (contact dermatitis and leg ulcer). The data indicated that test sera did not inhibit either spontaneous E rosette formation or active rosetting of normal lymphocytes.</p>  a0011-9059