01307nas a2200325   4500000000100000008004100001260000900042653002700051653002000078653001100098653002100109653001200130653002200142653001800164653001600182653001800198653002000216100001200236700001900248700001100267700001500278700001500293700001500308700001400323245010300337300001100440490000700451520050900458022001400967       1987                            d  c198710aAdjuvants, Immunologic10aCells, Cultured10aHumans10aInterferon-gamma10aleprosy10aPeptide Fragments10aT-Lymphocytes10aThymopentin10aThymopoietins10aThymus Hormones1 aMunno I1 aPellegrino N M1 aFumo G1 aBARBIERI G1 aPolimeno G1 aFilippis V1 aJirillo E00aEffects of a synthetic extract (thymopentin) on the immune system of lepromatous leprosy patients.  a167-730 v523 a<p>Twenty three patients with lepromatous leprosy (LL) not in reactional phase and bacteriologically negative were evaluated for their immune status (T cell frequency and interferon gamma production). In six patients with deficits of both immune parameters, a synthetic thymic extract (TP-5) was administered. At the end of the treatment, a full recovery of immune dysfunction was observed. In the light of these results, the efficacy of TP-5 as an immunomodulating agent in LL patients is discussed.</p>  a0011-4529