01820nas a2200349   4500000000100000008004100001260000900042653001000051653001000061653001100071653002000082653002100102653001100123653001200134653000900146653002000155653001300175653001600188653001300204653001300217100001600230700001300246700001500259700001500274700001200289700001200301245007000313300001100383490000600394520105600400022001401456       1988                            d  c198810aAdult10aChild10aFemale10aGenes, Dominant10aGenes, Recessive10aHumans10aleprosy10aMale10aModels, Genetic10aPedigree10aProbability10aSoftware10aThailand1 aWagener D K1 aSchauf V1 aNelson K E1 aScollard D1 aBrown A1 aSmith T00aSegregation analysis of leprosy in families of northern Thailand.  a95-1050 v53 a<p>Sixty-three families with multiple instances of leprosy were identified through a major leprosy treatment center in northern Thailand. Complex segregation analyses for single major genes or polygenic inheritance were performed using the maximum-likelihood routine POINTER to determine the most likely etiologic model of genetic susceptibility. Liability differences between men and women were considered in these models. When individuals were considered to be affected because they had any form of leprosy, a generalized major gene model with nearly dominant parameters on the liability scale, but additive penetrances, was found to be the most likely. When only those individuals who had tuberculoid forms of leprosy were considered to be affected, a recessive model was found to be the most likely; however, the discrimination between various models was poor. Further analyses are necessary to delineate genetic mechanisms to explain these apparently divergent results. In particular, methods of testing two locus models should be considered.</p>  a0741-0395