01407nas a2200301   4500000000100000008004100001260001300042653001900055653001100074653001800085653001200103653001200115653000900127653003900136653002300175653002800198653002000226653001700246653001200263100001500275700001100290700001400301245006500315300001000380490000700390520069400397022001401091       1987                            d  c1987 Apr10aAutoantibodies10aHumans10aLeishmaniasis10aleprosy10aMalaria10aMale10aonchocerciasis elimination mapping10aParasitic Diseases10aSchistosomiasis mansoni10aTrypanosomiasis10aTuberculosis10aTubulin1 aHoward M K1 aGull K1 aMiles M A00aAntibodies to tubulin in patients with parasitic infections.  a78-850 v683 a<p>Sera from a total of 268 patients with protozoan, helminth, bacterial (leprosy and tuberculosis) infections or appropriate controls, were assayed for anti-tubulin antibodies in an indirect enzyme-linked immunosorbent assay (ELISA), using purified tubulin as antigen. Levels of serum anti-tubulin antibody were significantly elevated in 67% of patients with visceral leishmaniasis, in 60% of patients with cutaneous leishmaniasis, in 89% of patients with onchocerciasis, in 100% of patients with schistosomiasis, and in 94% of patients with leprosy. Little or no increase in anti-tubulin antibody levels was seen in sera from patients with malaria (Plasmodium vivax) or tuberculosis.</p>  a0009-9104