01766nas a2200373   4500000000100000008004100001260001700042653001000059653001400069653001600083653002100099653001100120653001400131653001600145653001700161653001100178653001300189653001200202653001000214653000900224653001600233653001700249100001200266700001200278700001100290700001100301700001600312245003300328300001200361490000700373050003200380520096600412022001401378       1987                            d  c1987 Apr-Jun10aAdult10aBilirubin10aCholestasis10aErythema Nodosum10aFemale10aGranuloma10aHepatitis C10aHepatomegaly10aHumans10aJaundice10aleprosy10aLiver10aMale10aMiddle Aged10aSplenomegaly1 aKumar B1 aKoshy A1 aKaur S1 aKaur I1 aRajwanshi A00aLeprosy, liver and jaundice.  a194-2020 v59  aInfolep Library - available3 a<p>Nine patients of leprosy, 5 BL and 4 LL who developed jaundice during the course of disease were investigated. Two LL patients developed jaundice during ENL reaction. There was slight hepatomegaly in 5 patients and moderate splenomegaly in 3 only. There was significant alterations in liver enzymes and serum bilirubin in all patients. The abnormalities of the enzymes levels persisted for abnormally long periods even when the serum bilirubin had come down and the patients had become asymptomatic. Blood for HBsAg and anti-HAV IgM was negative in all the patients except one in whom HBsAg was positive. Drugs could not be implicated as the cause of jaundice, all patients maintained recovery even after restarting antileprosy drugs. The possibility of non A, non B viruses producing hepatitis during the course of disease is brought out. Course of prolonged jaundice in leprosy is compared with other diseases which could result in a similar situation.</p>  a0254-9395