02089nas a2200373   4500000000100000008004100001260001300042653003800055653002100093653002000114653001100134653003000145653001200175653002700187653002900214653000900243100001300252700001300265700001400278700001300292700001300305700001200318700001300330700001500343700001700358700001700375245006900392856009000461300000900551490000700560050001300567520112100580022001401701       1987                            d  c1987 Jul10aEnzyme-Linked Immunosorbent Assay10aErythema Nodosum10aGlucocorticoids10aHumans10aHypersensitivity, Delayed10aleprosy10aReceptors, Immunologic10aReceptors, Interleukin-210aSkin1 aTung K S1 aUmland E1 aMatzner P1 aNelson K1 aSchauf V1 aRubin L1 aWagner D1 aScollard D1 aVithayasai P1 aVithayasai V00aSoluble serum interleukin 2 receptor levels in leprosy patients.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1542234/pdf/clinexpimmunol00106-0019.pdf  a10-50 v69  aTUNG19873 a<p>Soluble interleukin 2 receptors (IL-2R) in sera of leprosy patients from Chiang Mai, Thailand, were quantified with a solid phase enzyme immunoassay using two monoclonal antibodies to the IL-2R. The IL-2R levels of untreated lepromatous, borderline lepromatous or midborderline patients and treated lepromatous and borderline lepromatous or treated borderline tuberculoid and tuberculoid patients were comparable to those of the Thai household or nonhousehold contacts; and they were significantly higher than the levels of USA control subjects. In contrast, IL-2R of untreated tuberculoid or borderline tuberculoid patients were significantly reduced. Patients with ongoing reversal reaction had very high circulating IL-2R, the levels of which correlated with fever and extent of skin lesions. Although erythema nodosum leprosum patients also had elevated IL-2R levels, they were significantly below those of patients with reversal reaction. When treated with corticosteroid, precipitous reduction of IL-2R was noted in all patients with reversal reaction but not in patients with erythema nodosum leprosum.</p>  a0009-9104