01519nas a2200241   4500000000100000008004100001260001300042653002000055653004100075653001100116653002100127653001800148653001200166100001100178700001500189700002000204700001300224245011500237300001000352490000700362520089400369022001401263       1987                            d  c1987 Nov10aCells, Cultured10aHistocompatibility Antigens Class II10aHumans10aInterferon-gamma10aLeishmaniasis10aleprosy1 aRada E1 aTrujillo D1 aCastellanos P L1 aConvit J00aGamma interferon production induced by antigens in patients with leprosy and American cutaneous leishmaniasis.  a520-40 v373 a<p>In this study, we measured gamma interferon production in mononuclear cell cultures from patients with diverse forms of leprosy and American cutaneous leishmaniasis. We studied patients with lepromatous, borderline lepromatous, borderline, and borderline tuberculoid forms of leprosy, as well as a Mitsuda-negative contact. In leishmaniasis we studied patients with localized cutaneous, mucocutaneous, and diffuse cutaneous forms of the disease. High correlation was observed between gamma interferon production and lymphocyte proliferation assays in both diseases. Resistant forms of both diseases showed significant reactivity, while the severe progressive forms were characterized by insignificant responses in both assays. Localized cutaneous leishmaniasis is characterized by variability in gamma interferon production, which may be of prognostic value in longitudinal studies.</p>  a0002-9637