01542nas a2200265   4500000000100000008004100001260001300042653001200055653003300067653001700100653001200117653001600129653000900145653002500154653001800179100001800197700001200215700001800227245008200245300001100327490000700338050003200345520088500377022001401262       1988                            d  c1988 Oct10aAnimals10aDrug Evaluation, Preclinical10aFluoresceins10aleprosy10aMacrophages10aMice10aMycobacterium leprae10aReceptors, Fc1 aJagannathan R1 aPatil D1 aMahadevan P R00aCorrelation of in vitro Fc receptor assay with in vivo mouse foot pad method.  a517-250 v60  aInfolep Library - available3 a<p>Resistant strains of M. leprae have been reported to the various antileprosy drugs. There is currently no accepted test to identify the susceptibility pattern of M. leprae to the drugs in a short period. The only accepted test is the mouse foot method which takes a long period to yield results. The Fc receptor assay using the ability of viable M. leprae to alter the membrane of the macrophage is well established. It takes only ten days and is inexpensive. In 6 cases of leprosy patients the susceptibility pattern was worked out both with the in vitro Fc receptor assay and the vivo in mouse foot method The results correlated very well leading to the fact that the assay system is reliable. Hence it can be used not only to study the status of a patient, but also to shortlist the number of compounds to be tested on the mouse foot pad as anti-leprosy drug candidates.</p>  a0254-9395