01483nas a2200277   4500000000100000008004100001260001300042653002900055653002400084653002000108653002500128653001100153653002100164653001200185653002500197100001200222700001500234700001400249700001300263245008900276856009000365300000900455490000700464520072000471022001401191       1987                            d  c1987 Jan10aAntigen-Presenting Cells10aAntigens, Bacterial10aAntigens, Viral10aHerpesvirus 4, Human10aHumans10aInterferon-gamma10aleprosy10aMycobacterium leprae1 aLindh J1 aAnderson U1 aBritton S1 aDe Ley M00aA single cell assay for the study of gamma-interferon formation in leprosy patients.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1542566/pdf/clinexpimmunol00112-0060.pdf  a51-40 v673 a<p>The number of gamma-interferon producing cells in the peripheral blood of leprosy (LL and BT) patients and controls was studied by the reversed protein A plaque assay before and after exposure in vitro to Mycobacterium leprae bacilli and Epstein-Barr virus (EBV). The level of spontaneous gamma-interferon production was significantly higher in BT patients compared to LL patients and controls. Mycobacterium leprae induced a specific gamma-interferon response in lymphocytes from BT patients and from healthy contacts whereas in LL patients and non-exposed controls the response was low or non-existing. There were no significant differences in the gamma-interferon response to EBV between the above groups.</p>  a0009-9104