01333nas a2200313   4500000000100000008004100001260001300042653001500055653001000070653001100080653001200091653001100103653001100114653001200125653000900137653001800146653002200164653003900186653001400225653001700239100001500256700001600271700001500287245008800302300000900390490000700399520059900406022001401005       1987                            d  c1987 Mar10aAdolescent10aAdult10aBiopsy10aDapsone10aFemale10aHumans10aleprosy10aMale10aMotor Neurons10aNeural Conduction10aPeripheral Nervous System Diseases10aPoisoning10aTibial Nerve1 aSirsat A M1 aLalitha V S1 aPandya S S00aDapsone neuropathy--report of three cases and pathologic features of a motor nerve.  a23-90 v553 a<p>We report the clinical features, electrophysiologic findings, and dapsone and isoniazid excretion studies in three young people who ingested excessive amounts (2-4 times the prescribed dose) of dapsone for hypopigmented macules and who developed, subacutely, progressive motor neuropathy a few months later. Pathologic studies on a biopsied motor nerve confirmed the electrophysiologic conclusion of distal motor axonopathy. All made a rapid recovery in a few months after dapsone was stopped, although electrical abnormalities persisted. One patient was a rapid acetylator of isoniazid.</p>  a0148-916X