01335nas a2200265   4500000000100000008004100001260001300042653001100055653001500066653002700081653001100108653001200119653002500131653001800156653002200174653003900196100001500235700001500250700001400265245004800279300001100327490000700338520071000345022001401055       1987                            d  c1987 Jul10aBiopsy10aCell Count10aDemyelinating Diseases10aHumans10aleprosy10aMicroscopy, Electron10aMyelin Sheath10aPeripheral nerves10aPeripheral Nervous System Diseases1 aJacobs J M1 aShetty V P1 aAntia N H00aTeased fibre studies in leprous neuropathy.  a301-130 v793 a<p>Nerve biopsies were taken from four cases of leprosy, which included borderline tuberculoid, borderline and lepromatous types. They were examined in 1-micron resin sections and in teased preparations. The most common finding in teased fibres from each leprosy type was paranodal demyelination affecting successive internodes. In transverse sections some fibres showed changes associated with axonal atrophy. Together, these findings suggest that demyelination in some cases may be secondary to axonal changes. In addition, there was evidence of focal areas of demyelination affecting whole internodes of many fibres at the same level across the nerve and which was possibly caused by local factors.</p>  a0022-510X