02049nas a2200337   4500000000100000008004100001260001200042653001700054653001600071653001400087653001400101653001700115653001800132653001200150653001400162653001300176100001100189700001600200700001300216700001400229700001400243700001500257700001100272700001300283245010000296856008000396300001000476490000900486520120200495022001401697       2026                            d  c08/202610aCase reports10aCoinfection10aCutaneous10aDiagnosis10adifferential10aLeishmaniasis10aleprosy10aPathology10asurgical1 aNeto M1 aFernandes J1 aFerraz A1 aMarelli J1 ade Lima M1 ada Silva C1 aKerr L1 aGurgel R00aCoinfection of Leprosy and American Cutaneous Leishmaniasis: A Case Report From Ceará, Brazil.  uhttps://pmc.ncbi.nlm.nih.gov/articles/PMC13547950/pdf/CARM-2026-3062648.pdf  a1 - 60 v20263 a<p>Leprosy and American cutaneous leishmaniasis are endemic diseases in Brazil that may coexist in the same host, particularly in coendemic regions. We report the case of a 68-year-old woman presenting with a six-month history of an ulcerated lesion on the left knee and concomitant disseminated annular plaques associated with sensory loss, madarosis, and peripheral nerve thickening. Histopathological examination of the ulcer demonstrated findings compatible with cutaneous leishmaniasis; immunohistochemistry using CD1a highlighted structures compatible with amastigotes, acknowledging its limitations. Biopsy of the plaques revealed a chronic granulomatous dermatitis with numerous acid-fast bacilli, corroborating multibacillary leprosy in the appropriate clinical context. The patient was treated with multidrug therapy for leprosy and intralesional meglumine antimoniate for leishmaniasis, with favorable outcomes. To the best of our knowledge, this is the first published report of such coinfection in Ceará. This case highlights the importance of sampling lesions with distinct morphologies and integrating clinical, histopathological, and laboratory findings in endemic settings.</p>
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