02512nas a2200253   4500000000100000008004100001260001900042653001300061653002000074653003000094653002700124653002200151653001000173100001400183700001200197700001200209700001200221245015500233856009800388300001100486490000700497520174000504022001402244       2026                            d  c09/2026bLepra10aVitiligo10aQuality of Life10aParticipation restriction10aPsychological Distress10aLeprosy diagnosis10aIndia1 aKesari PK1 aKumar S1 aSinha R1 aKumar R00aQuality of life, participation restriction, self-esteem and psychological distress in leprosy and vitiligo: a cross-sectional study from Eastern India  uhttps://leprosyreview.org/admin/public/api/lepra/website/getDownload/6ac5edadafaac1539c46cba2  a1 - 130 v973 a<p><strong>Background</strong></p>

<p>Leprosy and vitiligo are visible chronic skin conditions that can cause substantial psychosocial burden, but direct comparative evidence on quality of life, participation restriction, self-esteem and psychological distress is limited, particularly in the Indian context.</p>

<p><strong>Objectives</strong></p>

<p>This study compares dermatology-specific quality of life, participation restrictions, self-esteem and psychological distress between adults with leprosy and those with vitiligo attending a tertiary-care hospital in Eastern India.</p>

<p><strong>Methods</strong></p>

<p>In this cross-sectional observational study, 111 adult patients (56 leprosy, 55 vitiligo) completed the DLQI, Participation Scale, RSES and GHQ-12. Group differences were examined using independent t-tests, and hierarchical linear regressions assessed associations between diagnosis and psychosocial outcomes, adjusting for sociodemographic and clinical covariates.</p>

<p><strong>Results</strong></p>

<p>Patients with leprosy had significantly worse outcomes across all domains: DLQI (M = 11.04 vs. 5.62, p &lt; 0.001), Participation Scale (M = 28.73 vs. 11.51, p &lt; 0.001), RSES (M = 13.70 vs. 16.84, p &lt; 0.001) and GHQ-12 (M = 19.80 vs. 14.53, p &lt; 0.001). Diagnosis alone explained 35–46% of variance in these outcomes, while adding sociodemographic covariates produced only small, non-significant increments in explained variance.</p>

<p><strong>Conclusions</strong></p>

<p>In this tertiary-care setting in Eastern India, leprosy diagnosis was strongly associated with greater psychosocial burden than vitiligo after adjustment for selected sociodemographic variables.</p>
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