This study examines the human rights and social inclusion of persons affected by leprosy-related disabilities within the framework of the Global Leprosy Strategy 2021–2030. Despite significant medical advances, individuals affected by leprosy continue to experience stigma, discrimination, and social exclusion, which undermine their fundamental human rights. The study adopts a doctrinal and analytical approach to evaluate human rights standards, policy frameworks, and the strategic objectives of the Global Leprosy Strategy. The study finds that effective implementation of the strategy requires stronger legal protections, increased awareness, and inclusive policies that address both medical and socio-economic dimensions of leprosy. It concludes that promoting dignity, equality, and full participation of affected persons is essential to achieving sustainable development and the eradication of leprosy-related discrimination by 2030.