01284nas a2200193   4500000000100000008004100001260001200042653001500054653001600069653002100085100001100106700001500117700001500132245005100147300001400198490000600212520085800218022001401076       1981                            d  c01/198110aMetabolism10aClofazimine10aLeprosy patients1 aFeng P1 aFenselau C1 aJacobson R00aMetabolism of clofazimine in leprosy patients.  a521 - 5240 v93 a<p>We have identified two metabolites of clofazimine (B663; Lamprene; 3-(p-chloroanilino)-10-(p-chlorophenyl)-2,10-dihydro-2-isopropyliminophenazine) in our initial investigation of its metabolism in leprosy patients. Based on mass, ultraviolet, and visible spectrometry, we characterized an unconjugated (metabolite I, 3-(p-hydroxyanilino)-10-(p-chlorophenyl)-2,10-dihydro-2-isopropyliminophenazine ) and a conjugated (metabolite II, 3-(beta-D-glucopyranosiduronic acid)-10-(p-chlorophenyl)-2,10-dihydro-2-isopropyliminophenazine) metabolite from the urine of patients. Both metabolites were red in color, similar to clofazimine; however, both were considerably more polar than the parent drug. We suggest that metabolite I was formed by a hydrolytic dehalogenation reaction, and metabolite II by hydrolytic deamination followed by glucuronidation.</p>  a0090-9556