01880nas a2200193   4500000000100000008004100001260004700042653001700089653001800106100001600124700002000140700001900160245009900179856007500278300001400353490000700367520129700374022001501671       2026                            d  c03/2026bForum Ilmiah Kesehatan (FORIKES) 10aRisk factors10aclose contact1 aPuji Utami 1 aTiti Indriyati 1 aSumiati Bedah 00aClose Contact with Patients and Immunity Status as Major Risk Factors for Leprosy Among Adults  uhttps://forikes-ejournal.com/index.php/SF/article/view/sf170308/170308  a235 - 2380 v173 a<p>Leprosy is a chronic infectious disease caused by&nbsp;<em>Mycobacterium leprae</em>&nbsp;that affects peripheral nerves, skin, the upper respiratory tract, eyes, and nasal mucosa. Despite global progress, it remains a public health problem in Indonesia. This study aimed to analyze the risk factors associated with leprosy among adults at UPT RSUD RAA Soewondo Pati in 2025. An analytical observational study with a case–control design was conducted involving 70 cases and 70 controls (1:1 ratio). Data were analyzed using Chi‑square tests and multivariate logistic regression. In results, age (p=0.007), sex (p=0.033), close contact with leprosy patients (p=0.005), personal hygiene (p=0.011), and immunity status (p=0.000) were significantly associated with leprosy. Multivariate analysis identified close contact with leprosy patients (OR=8.3; 95% CI: 1.897–36.310) and immunity status (OR=6.2; 95% CI: 2.798–13.570) as the strongest predictors. In conclusion, close contact with leprosy patients and compromised immunity status are the major risk factors for leprosy among adults. Strengthening early detection, monitoring close contacts, improving personal hygiene, and enhancing community immunity are essential strategies to reduce transmission and prevent new cases.</p>
  a2086-3098