01960nas a2200217   4500000000100000008004100001260002500042653002300067653001400090653002400104100001200128700002000140700001200160700001700172700001800189245009600207856015300303300001100456520126100467022001401728       2026                            d  c04/2026bElsevier BV10aGlomerulonephritis10aInfection10aMycobacterium avium1 aVisch R1 avan Laarhoven A1 aSmits L1 avan Midden D1 avan de Logt A00aIgA Dominant Infection-Related Glomerulonephritis due to Mycobacterium avium: A Case Report  uhttps://www.sciencedirect.com/science/article/pii/S2590059526001457/pdfft?md5=7dbcf844495d27f840d88e50cde48121&pid=1-s2.0-S2590059526001457-main.pdf  a1 - 233 a<p>Immunoglobulin A-dominant infection-related glomerulonephritis (IgA-DIRGN) is a rare variant of acute postinfectious glomerulonephritis (GN), typically seen in elderly individuals with comorbidities. IgA-DIRGN is characterized by diffuse endocapillary proliferation and the formation of mesangial deposits of IgA and C3, leading to inflammation and subsequently resulting in acute kidney injury, proteinuria, hematuria, and hypocomplementemia. In this report, we describe an immunocompromised 68-year-old male who developed acute kidney injury, nephrotic-range proteinuria, and microscopic hematuria following a splenic&nbsp;<em>Mycobacterium avium</em>&nbsp;abscess. Kidney biopsy revealed endocapillary proliferative GN with IgA and C3-dominant granular deposits, consistent with IgA-DIRGN. Progression of renal dysfunction during antimycobacterial therapy prompted the use of glucocorticoids one month after the initial presentation and eventually a splenectomy one month later, followed by renal recovery. To our knowledge, this is the first case to report the association between a non-tuberculous mycobacterial infection and IgA-DIRGN, emphasizing the importance of source control and illustrating the usefulness of steroids in this patient.</p>
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