02200nas a2200301 4500000000100000008004100001260001200042653002500054653002200079653001200101653001900113100001500132700001100147700001700158700001500175700001700190700001600207700001600223700001400239700001600253700001400269700001500283245009000298856026000388300000900648520122700657022001401884 2026 d c02/202610aMycobacterium leprae10acutaneous leprosy10aleprosy10amigrant health1 aPonzetta L1 aVita S1 aCorpolongo A1 aD'Abramo A1 aScarabello A1 aMencarini P1 aLibertone R1 aDi Bari V1 aBartolini B1 aVulcano A1 aNicastri E00aAtypical Cutaneous Manifestations of Leprosy in a Non-Endemic Country: A Case Report. uhttps://pdf.sciencedirectassets.com/272925/AIP/1-s2.0-S147789392600013X/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEKL%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEaCXVzLWVhc3QtMSJHMEUCIQC2GJ%2BvpoZ%2Bm8dKWEKhhBOufNuDnWk6b%2BZzmfYVsir0xAIgbLZZ6GEUbtprwUompuyUUWfRnv0 a1-113 a

BACKGROUND:

Leprosy, caused by Mycobacterium leprae, can pose diagnostic challenges in non-endemic regions because of its low frequency and possible atypical presentations.

CASE PRESENTATION:

This case describes the unusual clinical manifestations of leprosy in a 52-year-old Indian woman who immigrated to Italy: she presented with a granulomatous nasal plaque and hypopigmented abdominal lesion, without evidence of sensory loss or peripheral neuropathy. Initial evaluations were inconclusive, causing a significant diagnostic delay. Definitive diagnosis was achieved by molecular test for Mycobacterium leprae from respiratory and skin samples. After 12 months of multidrug therapy, the nasal lesion resolved completely.

CONCLUSIONS:

This case highlights the imperative for health care providers in nonendemic settings to always consider leprosy in the differential diagnosis of chronic dermatologic conditions, especially in individuals with relevant epidemiologic background, even in absence of typical manifestations, emphasizing the need for high clinical suspicion and multidisciplinary collaboration.

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