01771nas a2200325   4500000000100000008004100001260001300042653001500055653001000070653000900080653002000089653001100109653001100120653002200131653002300153653001200176653001600188653000900204653001600213653001400229653001600243100001400259700001700273245009000290856009000380300001000470490000700480520094400487022001401431       1985                            d  c1985 Apr10aAdolescent10aAdult10aAged10aCells, Cultured10aFemale10aHumans10aHydrogen Peroxide10aImmunity, Cellular10aleprosy10aMacrophages10aMale10aMiddle Aged10aMonocytes10aSuperoxides1 aSharp A K1 aBanerjee D K00aHydrogen peroxide and superoxide production by peripheral blood monocytes in leprosy.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1577001/pdf/clinexpimmunol00133-0212.pdf  a203-60 v603 a<p>Susceptibility to infection with Mycobacterium leprae, the causative organism of leprosy, is the result of a defect in cell-mediated immunity (CMI). The co-operation of macrophages and T lymphocytes is known to be essential for competent CMI response. In this study we have examined peripheral blood monocytes from a range of leprosy patients in an attempt to identify a possible defect in macrophage function. The ability of these cells to produce hydrogen peroxide and superoxide, two bactericidal metabolites of the monocyte/macrophage, has been measured. Monocytes from leprosy patients were found to be capable of producing normal amounts of hydrogen peroxide and superoxide, and no differences in production were found between tuberculoid, lepromatous and control monocytes. These results suggest that macrophages in leprosy are competent, and that probably a T lymphocyte defect contributes to susceptibility to this disease.</p>  a0009-9104